There are no clinical studies at present with nao® brain stimulation. Because of the ingredients, you should observe the following note: nao® brain stimulation is not suitable for adults who cannot consume caffeine due to an illness. The consumption of caffeine-containing products such as nao® brain stimulation can have interactions with various medications. If medicines such as sympathomimetics are taken, heart rate can climb, and reinforce the effects of caffeine. Caffeine counteracts calming medicines. Furthermore, caffeine increases the efficacy of pain relievers containing acetylsalicylic acid or Paracetamol. Possible interactions with medicines taken for on-going therapy should be discussed with your doctor.